Here is a test if anyone doubts the power of the gun they carry. Get a pine board, baseball bat, 2x4 or anything similar you are confident will smash the skull of whatever it is you are defending yourself from. Take your weapon and shoot that thing and if it fully penetrates you know it will be adequate for whatever it is you are doing.
If the 22lr is so bad then why did the OSS, which was the best of the best and expected to make kills with one shot use a suppressed 22 LR? That means the gun used a lesser load and shot through a suppressor which also lowered the velocity so the 22LR they used was weaker than the good stuff a person would carry today.