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Old November 22nd, 2013 #1
Jae Manzel
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Join Date: Aug 2013
Posts: 1,066
Default Scientists discover the 'Pierce Brosnan gene' that gives some people freckles, dark brown hair and blue eyes

A ‘Pierce Brosnan gene’ which causes people to develop freckles, brown hair and blue eyes has been discovered by scientists.

A study of 2,230 people in Iceland identified a gene variant that is strongly related to sensitivity to the sun, brown hair, blue eyes, and freckles.

Normally, the further from the equator people come from, the less pigmentation they have in their skin, hair and eyes.



A 'Pierce Brosnan gene' which causes people to develop freckles, brown hair and blue eyes has been discovered by scientists

This makes them more sensitive to the sun, but means they can more easily absorb sunlight to generate vitamin D3, a nutrient important for healthy bones.

The study looked at a particular variant in the gene IRF4 which is part of the immune system and produces a protein that helps to fight off viruses and harmful bacteria.

IRF4 appears to act like a 'dimmer switch' regulating the amount of melanin in surface skin cells, called keratinocytes, which protect us from the UV light which causes sunburn.


The findings could provide insights into skin diseases, such as melanoma. Lindsay Lohan (pictured) could also have the gene variant

They discovered a variant of IRF4 can reduce the amount of melanin getting to the keratinocytes resulting in freckles, but they still haven't found the exact cause, according to the study published in the journal Cell.

Dr Dan Kastner, Scientific Director of the National Human Genome Research Institute, in Bethesda near Washington, said: ‘Genes involved in skin pigmentation also have important roles in human health and disease.

‘This study explains a complex molecular pathway that may also contribute insights into skin diseases, such as melanoma, which is caused by the interaction of genetic susceptibility with environmental factors.’

Dr William Pavan, co-author and senior investigator at the Genetic Disease Research Branch said: ‘Genome-wide association studies are uncovering many genomic variants that are associated with human traits and most of them are found in non-protein-coding regions of the genome.

‘Exploring the biological pathways and molecular mechanisms that involve variants in these under-explored portions of the genome is a challenging part of our work.

‘This is one of a few cases where scientists have been able to associate a variant in a non-coding genomic region with a functional mechanism.’

http://www.dailymail.co.uk/health/ar...cientists.html
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The rest of you are nothing more than a livestock – you were created for us: to serve in that or the other way.
 
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